Advancing SUDEP Risk Prediction Using a Multicenter Case-Control Approach

First-in-human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation

M Patros, DGS Farmer, K Moneghetti, MM Ottaviani, S Sivathamboo, HD Simpson, TJ O'Brien, VG Macefield

2024-12-01

Introduction: Vagus nerve stimulation (VNS) is an effective treatment for people with drug-resistant epilepsy. However, its mechan..

Applying the ILAE diagnostic criteria for Lennox-Gastaut syndrome in the real-world setting: A multicenter retrospective cohort study

Russell Nightscales, Zhibin Chen, Sarah Barnard, Clarissa Auvrez, Gerard Tao, Shobi Sivathamboo, Caitlin Bennett, Maria Rychkova, Wendyl D'Souza, Samuel F Berkovic, John-Paul Nicolo, Terence J O'Brien, Piero Perucca, Ingrid E Scheffer, Patrick Kwan

2024-04-01

Objective: Lennox-Gastaut syndrome (LGS) is an archetypal developmental and epileptic encephalopathy, for which novel treatments a..

Sleep and respiratory abnormalities in adults with developmental and epileptic encephalopathies using polysomnography and video-EEG monitoring

S Sivathamboo, KA Myers, A Pattichis, EJ White, KN Ku, TJ O'Brien, P Perucca, P Kwan

2023-09-01

This study evaluated sleep and respiratory abnormalities, and their relationship with seizures, in adults with developmental and e..

Interictal EEG and ECG for SUDEP Risk Assessment: A Retrospective Multicenter Cohort Study

ZS Chen, A Hsieh, G Sun, GK Bergey, SF Berkovic, P Perucca, W D'Souza, CJ Elder, P Farooque, EL Johnson, S Barnard, R Nightscales, P Kwan, B Moseley, TJ O'Brien, S Sivathamboo, J Laze, D Friedman, O Devinsky, DC Hesdorffer

2022-03-18

Objective: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality. Although lots of effort..